Benadryl challenge meme
✕ Risky for brands. This meme is associated with dangerous drug overdose and is highly inappropriate for any business to reference.
What does the Benadryl challenge meme mean?
The Benadryl challenge is an internet trend where participants consume excessive amounts of the antihistamine diphenhydramine to induce hallucinations.
Where did Benadryl challenge come from?
The Benadryl challenge is an internet challenge that emerged in 2020, revolving around the deliberate consumption, excessive use and overdose of the antihistamine medicine diphenhydramine (commonly sold in the United States under the brand name Benadryl), which acts as a deliriant in high doses. The challenge, which reportedly spread via the social media platform TikTok, instructs participants to film themselves consuming large doses of Benadryl and documenting the effect of tripping or hallucinating.
Is the Benadryl challenge meme dead?
Less than it was. Benadryl challenge is fading: its rate of reads of its Wikipedia article has slowed by more than 15% compared with the period before. Its current rate is 2% of its peak, which came in the period ending Jul 1, 2026.
The Wikipedia article on Benadryl challenge was read 171 times in November 2026, and 648,100 times since July 2015. Its busiest measured month ended Jul 1, 2026 at 1,334 reads per day.
Stats
| Busiest month | June 2026 (40,020 reads) |
| Reads, last 12 months | 124,326 |
| Reads, 12 months before | 115,239 |
| Change year on year | +8% |
| All-time reads since July 2015 | 648,100 |
| Current rate vs peak | 2% of the peak in the period ending Jul 1, 2026 |
Benadryl challenge captions for businesses
| real estate | We do not recommend this meme for real estate businesses. |
| dentists | We do not recommend this meme for dental practices. |
| restaurants | We do not recommend this meme for restaurants. |
| fitness studios | We do not recommend this meme for fitness studios. |
| software startups | We do not recommend this meme for software startups. |
| coffee shops | We do not recommend this meme for coffee shops. |
| hair salons | We do not recommend this meme for hair salons. |
| accountants | We do not recommend this meme for accountants. |
More questions
Can a business post the Benadryl challenge meme?
Be careful. This meme is associated with dangerous drug overdose and is highly inappropriate for any business to reference. memeidea's brand-safety calls are AI-assisted suggestions, so check how the format is being used this week before posting.
What is a good Benadryl challenge caption for a business?
For real estate: “We do not recommend this meme for real estate businesses.”. For dentists: “We do not recommend this meme for dental practices.”. For restaurants: “We do not recommend this meme for restaurants.”. More captions are in the table above.
Sources
- Wikipedia: Benadryl challenge: article and page-view counts (Wikimedia API)
- Know Your Meme: origin and spread
- memeidea method: how stages and momentum are measured