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Benadryl challenge

Benadryl challenge meme

FadingStage
171Reads last month
648,100All-time reads

✕ Risky for brands. This meme is associated with dangerous drug overdose and is highly inappropriate for any business to reference.

What does the Benadryl challenge meme mean?

The Benadryl challenge is an internet trend where participants consume excessive amounts of the antihistamine diphenhydramine to induce hallucinations.

Where did Benadryl challenge come from?

The Benadryl challenge is an internet challenge that emerged in 2020, revolving around the deliberate consumption, excessive use and overdose of the antihistamine medicine diphenhydramine (commonly sold in the United States under the brand name Benadryl), which acts as a deliriant in high doses. The challenge, which reportedly spread via the social media platform TikTok, instructs participants to film themselves consuming large doses of Benadryl and documenting the effect of tripping or hallucinating.

From the introduction of the Wikipedia article (CC BY-SA 4.0).

Is the Benadryl challenge meme dead?

Less than it was. Benadryl challenge is fading: its rate of reads of its Wikipedia article has slowed by more than 15% compared with the period before. Its current rate is 2% of its peak, which came in the period ending Jul 1, 2026.

The Wikipedia article on Benadryl challenge was read 171 times in November 2026, and 648,100 times since July 2015. Its busiest measured month ended Jul 1, 2026 at 1,334 reads per day. As of Nov 7, 2026.

Wikipedia reads/day (peak 1,334) Dec 20Dec 21Dec 22Dec 23Dec 24Dec 25Nov 26

Stats

Busiest monthJune 2026 (40,020 reads)
Reads, last 12 months124,326
Reads, 12 months before115,239
Change year on year+8%
All-time reads since July 2015648,100
Current rate vs peak2% of the peak in the period ending Jul 1, 2026

Other formats that are fading right now: Rule 34, 6-7, Italian brainrot, Kirkification, Lean (drug).

Benadryl challenge captions for businesses

real estateWe do not recommend this meme for real estate businesses.
dentistsWe do not recommend this meme for dental practices.
restaurantsWe do not recommend this meme for restaurants.
fitness studiosWe do not recommend this meme for fitness studios.
software startupsWe do not recommend this meme for software startups.
coffee shopsWe do not recommend this meme for coffee shops.
hair salonsWe do not recommend this meme for hair salons.
accountantsWe do not recommend this meme for accountants.

More questions

Can a business post the Benadryl challenge meme?

Be careful. This meme is associated with dangerous drug overdose and is highly inappropriate for any business to reference. memeidea's brand-safety calls are AI-assisted suggestions, so check how the format is being used this week before posting.

What is a good Benadryl challenge caption for a business?

For real estate: “We do not recommend this meme for real estate businesses.”. For dentists: “We do not recommend this meme for dental practices.”. For restaurants: “We do not recommend this meme for restaurants.”. More captions are in the table above.

Sources

Image: Wikimedia Commons (free licence; see file page for author and terms).